Knowledge and Attitude of Kinshasa Women Towards the Dangers of Excessive Use of Corticosteroids and Cyproheptadine in Order to Gain Weight: Cross-Sectional and Analytical Study

Author's Information:

Kapitene Kamuanga Michael 

Department of Family Medicine and Primary Health Care of the Protestant University in Congo, Democratic Republic of Congo.

Department of Public Health, John Wesley Methodist University, Kinshasa, Democratic Republic of Congo.

Micha'gloire Medical-Surgical and Maternity Center, Kinshasa, Democratic Republic of Congo.

Orcid: https://orcid.org/0009-00001-4366-6713

Ehomba Memba Pierre

Department of Family Medicine and Primary Health Care of the Protestant University in Congo, Democratic Republic of Congo.

Mbanda Npunza Claudia

Department of Public Health, John Wesley Methodist University, Kinshasa, Democratic Republic of Congo.

Micha'gloire Medical-Surgical and Maternity Center, Kinshasa, Democratic Republic of Congo.

Ntumba Tshiteya Mireille

Micha'gloire Medical-Surgical and Maternity Center, Kinshasa, Democratic Republic of Congo.

Vol 2 No 08 (2025):VOLUME 02 ISSUE 08 AUGUST 2025

Page No.: 60-69

Abstract:

Introduction: It is a cultural issue related to feminine aesthetics that has given rise to men's taste for plump women with roundness. Thin women, especially those who appreciate pants, dresses or skirts thattightenthe body, feel self-conscious and engage in the practice of abusing corticosteroids and cyproheptadine for weight gain. This practice consists of taking Cyproheptadine syrup, mixing it with 60 corticosteroid tablets, and then taking it orally before going to sleep. This is repeated every 5 days. The aim of this study is toto determine the prevalence of Kinshasa women consuming corticosteroids and cyproheptadine in order to gain weight, as well as their levels of knowledge and their attitude towards the resulting dangers and risks.

Methods: It was a cross-sectional and analytical study carried outamong women aged 15 to 35 residing in the city of Kinshasa, in the DR Congo. The selection of participants was made in the 4 districts of the City. Women who knew the usecorticosteroids/cyproheptadine for weight gain were selected.Study parameters included sociodemographic data, prevalence and determinants of corticosteroid and cyproheptadine consumption.

Results: A total of 260 respondents (average age21.12 ± 3.49 years), singles (84%), of secondary education level (54%) and having no occupation or unemployed (81.53%). The majority of respondents, 98.84%, are aware of the types of corticosteroids/cyproheptadine; 98.41% of respondents say they know the weight gain effects of these products. In addition, 94.21% of respondents consume corticosteroids/cyproheptadine for weight gain. As for knowledge of the side effects and illnesses related to taking these corticosteroids/cyproheptadine, 92.69% of respondents knew its side effects and illnesses and identified obesity as a complication and illness in 56.53% of cases. The majority, 88.07% of those surveyed, had the attitude of taking thecorticosteroids/cyproheptadine despite their knowledge of the side effectsand the complications of this taking. But in 80.38% of cases, these respondents did not know the seriousness of the side effects resulting from this intake.

Conclusion: The single Kinoise, with a secondary education and no profession, knows the types of corticosteroids/cyproheptadine, knows the weight gain effects of these products, and consumes them for the purpose of weight gain. She also knows the side effects and diseases that can result from taking them, citing obesity without knowing the seriousness of these side effects. But, she has the attitude of still consuming themcorticosteroids/cyproheptadine.

KeyWords:

corticosteroids, cyproheptadine, knowledge, attitude, Kinshasa, Congo

References:

  1. Lévy, JJ Thoër, C. (2008). Non-medical drug use among adolescents and young adults: Empirical perspectives. Drugs, Health and Society, 7(1), 153–189. https://doi.org/10.7202/019622ar
  2. Mahmoud Amine Laffinti, Jalal El Ouadoudi, Hicham Guennouni Hassani, Rachid Najib, Abdeslam Benali. Corticosteroids and culture: a case of acute corticosteroid-induced psychotic episode. The Pan African Medical Journal. 2019;33:25. doi:10.11604/pamj.2019.33.25.18207
  3. Kenna HA, Poon AW, de los Angeles CP, Koran LM. Psychiatric complications of treatment with corticosteroids: review with case report: corticosteroid psychiatric complications. Psychiatry and Clinical Neurosciences. Oct 2011;65(6):54960. PubMed | Google Scholar
  4. La Dépêche. In the DRC, women risk their health to have rounder buttocks. https://www.ladepeche.fr/article/2012/03/08/1301083-en-rdc-des-femmes-riskent-leur-sante-pour-avoir-des-fesses-plus-rebondies.html, Accessed on 08/22/2022
  5. Apolline Henry, (2022). Periactin: why it is not a good idea to use this drug to gain weight. https://www.topsante.com/medecine/medicaments/automedication/periactin-pourquoi-ce-n-est-pas-une-bonne-idee-d-utiliser-ce-medicament-pour-gr-648150, Accessed on 08/22/2022
  6. Marion Guérin and Julie Giorgetta. Cortisone, corticosteroids: definition, effects, without prescription? https://sante.journaldesfemmes.fr/fiches-medicaments/2500168-cortisone-corticoide-definition-effects-infiltration-creme-definition-liste-medicament-indication-ordre/ To consult 01/07/22
  7. Vidal (2019). In which case is the drug solupred prescribed? https://www.vidal.fr/medicaments/gammes/solupred-9548.html, Accessed on 08/22/2022
  8. Akbar K Waljee, Mary AM Rogers, Paul LiAmit G Singal, Joshua D Stein,Rory M Marks, John Z Ayanian, Brahmajee K Nallamothu. Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study BMJ2017;357 doi:https://doi.org/10.1136/bmj.j1415
  9. Pharmacomedical. Corticosteroids : the essential points. https://pharmacomedicale.org/medicaments/par-specialites/item/corticoides-les-points-essentiels, Accessed on 08/22/2022
  10. Mahmoud Amine LaffintiJalal El OuadoudiHicham Guennouni HassaniRachid Najib And Abdeslam Benali. Corticosteroids and culture: a case of acute corticosteroid-induced psychotic episode. Pan Afr Med J. 2019; 33: 25. DOI:10.11604/pamj.2019.33.25.18207
  11. Zavier ZomalhetoHilaire Dossou-yovoFaithful Zossoungbo And Martin Avimadjè. Prevalence of complications of corticosteroid therapy in West African subjects consulting in rheumatology. Pan Afr Med J. 2015; 21: 304. DOI:10.11604/pamj.2015.21.304.5805
  12. Perdoncini-Roux Aurelie, Blanchon Thierry, Hanslik Thomas, Lasserre Andrea, Turbelin Corinne, Dorleans Yves, Cabane Jean-Paul, Fardet Laurence. General practitioners' perception of the discomfort induced by the adverse effects of prolonged systemic corticosteroid therapy, Revue d. Epidémiologie et de Sante Publique. 2009;57(2):93–7. [PubMed] [Google Scholar]
  13. Vidal.  Active substance cyproheptadine. https://www.vidal.fr/medicaments/substances/cyproheptadine-15552.html, Accessed on 08/22/2022
  14. Catalog and Index of French-Language Medical Sites (Cismef). Cyproheptadine, MeSH Descriptor. https://www.cismef.org/page/cyproheptadine, consulted on 18 9 22
  15. Pharmacoshopi. Cyproheptadine. https://www.pharmashopi.com/cyproheptadine-rr-30-1750.html, Accessed on 08/22/2022
  16. ANSM. Periactine 4mg (cyproheptadine): risks associated with non-compliant use as an orexigenic agent for aesthetic purposes. https://ansm.sante.fr/information-de-securite/periactine-4-mg-cyproheptadine-risks-lies-a-lusage-non-conforme-comme-orexigene-a-des-fins-esthetiques, Accessed on 08/22/2022
  17. Familiprix. Pms Cyprohepadine 4mg tablet. https://www.familiprix.com/fr/medicaments/pms-cyproheptadine-4mg-comprime-00757713, Accessed on 08/22/2022
  18. Therapeutics Magazine. Cyproheptadine HCl: side effects and indications. https://therapeutesmagazine.com/cyproheptadine-hcl-effects-secondaires-et-indications/,  Accessed on 08/22/2022
  19. National Agency for the Safety of Medicines and Health Products (ANSM). Periactine 4 mg (cyproheptadine): risks associated with off-label use as an orexigenic agent for aesthetic purposes. https://www.ordre.pharmacien.fr/Communications/Les-actualites/Periactine-4-mg-cyproheptadine-risks-lies-al-utilization-non-conforme-comme-orexigene-a-des-fins-esthetiques, Accessed on 08/22/2022
  20. SRLF, STC, SFMU. Management of drug and recreational drug poisoning. https://www.srlf.org/wp-content/uploads/2020/06/RFE-Toxico-SRLF-2020.pdf, Accessed on 08/22/2022