Medical Science Research Bulletin

Fetal macrosomia generally occurs when the estimated weight of the fetus exceeds the expected threshold, irrespective of gestational age. It is defined as a fetus larger than 4000 to 4500 grams. Documented risk factors for macrosomia include maternal birth weight, gestational or preexisting Diabetes mellitus, obesity, age >35 years, excessive gestational weight gain, multiparity, male fetus, previous history of macrosomia and intrinsic fetal factors such as congenital, cytogenetic and other syndromic fetal abnormalities. We present a case of an unbooked 28-year-old woman who delivered a 6kg newborn in a fertility centre in Lagos. 

Macrosomia, unbooked pregnancy, multiparity.

1. Turkmen S, Johansson S, Dahmoun M. Foetal Macrosomia and Foetal-Maternal Outcomes at Birth. J Pregnancy. 2018 Aug 8;2018:4790136. Doi: 10.1155/2018/4790136. PMID: 30174954; PMCID: PMC6106949. 
2. Macrosomia: ACOG Practice Bulletin, Number 216. Obstet Gynecol 2020; 135:e18. Reaffirmed 2023.
3. Ng SK, Olog A, Spinks AB, Cameron CM, Searle J, McClure RJ. Risk factors and obstetric complications of large for gestational age births with adjustments for community effects: Results from a new cohort study. BMC Public Health 2010 Aug 6; 10:460. Doi: 10. 1186/1471-2458-10-460. PMID: 20687966; PMCID: PMC2921393. 
4. Oluwole AA, Omisakin SI, Ugwu AO. A Retrospective Audit of Placental Weight and Fetal Outcome at the Lagos University Teaching Hospital, Southwest Nigeria. International Journal of Medicine and Health Development. 2024 Sep 18;29(4):305–9. http://dx.doi.org/10.4103/ijmh.ijmh_44_24.
5. Asplund CA, Seehusen DA, Callahan TL, Olsen C. Percentage change in antenatal body mass index as a predictor of neonatal macrosomia. Ann Fam Med 2008 nov-Dec;6(6):550‑4. Doi: 10. 1370/afm.903.PMID: 19001308; PMCID: PMC2582460. 
6. Adegbola O, Habeebu-Adeyemi FM. Fetal Macrosomia at a Tertiary Care Centre in Lagos, Nigeria. Nig Q J Hosp Med. 2015 Apr-Jun;25(2):90-94. PMID: 27295826. 
7. Hermann GM, Dallas LM, Haskell SE, Roghair RD. Neonatal macrosomia is an independent risk factor for adult metabolic syndrome. Neonatology 2010;98(3):238‑44. Doi: 10. 1159/000285629. Epub 2010 Apr 13. PMID: 20389129; PMCID: PMC2935261. 
8. Araujo Júnior E, Peixoto AB, Zamarian AC, Elito Júnior J, Tonni G. Macrosomia. Best Pract Res Clin Obstet Gynaecol. 2017;38:83-96. doi:10.1016/j.bpobgyn. 2016.08.003
9. Tabatabaee SH, Mohammadbeigi A, Yazdani M, Zeighami B, Mohammadsalehi N. Gestational diabetes risk factors modelling in pregnant women. Int J Diab Dev Ctries 2007;27:11‑3.
10. Liu CH, Yang ST, Wang PH. Maternal factors associated with fetal macrosomia. J Chin Med Assoc. 2023;86(5):455-456. doi:10.1097/JCMA.0000000000000894
11. Vetr M. Risk factors associated with high birth weight deliveries. Ceska Gynekol 2005 Sep; 70(5): 347-54. Czech. PMID: 16180794. 
12. Najafian M, Cheraghi M. Occurrence of fetal macrosomia rate and its maternal and neonatal complications: a 5- year cohort study. ISRN Obstet Gynecol 2012;2012:353791. Doi: 10. 5402/2012/353791. Epub 2012 Nov 14. PMID: 23209925; PMCID: PMC3504382.
13. Oluwole AA, Ugwu AO. Impact of first-trimester body mass index on pregnancy outcomes: observational study. Annals of Clinical and Biomedical Research. 2023 Mar 7;4(1). http://dx.doi.org/10.4081/acbr.2023.273. 
14. Mulik V, Usha Kiran TS, Bethel J, Bhal PS. The outcome of macrosomic fetuses in low risk primigravid population. Int J Gynaecol Obstet. 2003 Jan; 80(1):15-22. Doi: 10. 1016/s0020-7292(02)00332-6. PMID: 12527455. ,